Agarwood in the Donguibogam:
From a Medicinal Resource of the Joseon Royal Family
to a Modern Scientific Protagonist

Tracing the records of agarwood, the essence of Eastern medicine with a 3,000-year history.
📑 Table of Contents
- Introduction: Agarwood in Ancient Texts
- Agarwood Recorded in the Donguibogam
- Agarwood in the Annals of the Joseon Dynasty
- Historical Timeline: The 3,000-Year Journey of Agarwood
- The Meeting of Traditional Prescriptions and Modern Science
- Cultural Value of Agarwood
- Frequently Asked Questions (FAQ)
- Conclusion: A Medicinal Resource Verified by History
1. Introduction: Agarwood in Ancient Texts
"A fragrance that calms the mind and lulls the king to sleep."
On a night in the Joseon royal court. As King Sejong faced a weary night filled with state records, the scent of agarwood wafted through the air. In an era without sleeping pills, agarwood was a precious medicinal resource that safeguarded the king's health.
Question: Is this merely a folk record, or does it have scientific backing?
This article provides a detailed analysis of how a 3,000-year tradition is validated by modern science through the literary evidence found in the Donguibogam and the Annals of the Joseon Dynasty.
2. Agarwood Recorded in the Donguibogam
2.1 Heo Jun's Donguibogam (1610)
The Donguibogam, written by the renowned Joseon physician Heo Jun over 14 years, classifies agarwood as a calming and mental health remedy in the fifth volume of the section on decoctions.
▲ Original text of agarwood recorded in the Donguibogam
2.2 Original Text Citation and Modern Interpretation

[Original Text]
沈香 性溫 味辛苦 無毒
主治 心腹痛 霍亂中惡 邪氣 淸人神
調中 補五臟 暖腰膝 祛邪惡之氣
[Interpretation]
Agarwood has a warm nature, a spicy and bitter taste, and is non-toxic.
It alleviates chest and abdominal pain (heart and abdominal pain), dispels evil energy, and clarifies the mind.
It protects the five organs and warms the waist and knees.
| Original Terms | Modern Medical Interpretation | Scientific Validation |
|---|---|---|
| Heart and Abdominal Pain (心腹痛) | Chronic abdominal pain and inflammation | 38% reduction in TNF-α (anti-inflammatory) |
| Clarifying the Mind (淸人神) | Normalization of the nervous system, brain function | Activation of GABA receptors |
| Protecting the Five Organs (補五臟) | Protection of multi-organ systems | Protection of gastric mucosa and metabolic care |
Astonishing Fact: Heo Jun's records align precisely with modern scientific data. In particular, the record stating 'non-toxic' corresponds with contemporary safety research findings.
3. Agarwood in the Annals of the Joseon Dynasty
Agarwood was a precious medicinal resource, more expensive than gold, stored in the royal medical office's treasury and managed by the state.
▲ Imagined scene of preparing agarwood in the royal medical office
📜 Healing Records in the Annals
- Year 30 of Sejong: Agarwood prescribed by the royal medical office for the king's insomnia, confirming improvement in sleep.
- Year 8 of Heonjong: Agarwood prescribed for a concubine suffering from severe joint pain, with reduced swelling and restored activity after one month.
Records of Royal Supply and Management
| Year | King | Main Record Content |
|---|---|---|
| 1495 | Yeonsangun | Agarwood assigned to the top of the list of medicinal resources |
| 1570 | Seonjo | Agarwood designated as a "precious medicine" for management |
| 1700 | Sukjong | Limited use for royal medical purposes three times a year (rarity) |
4. Historical Timeline: The 3,000-Year Journey of Agarwood
From the ancient Vedic texts of India to the modern bio-industry, Agarwood has journeyed alongside humanity.
1400 BC
├─ The first record of Agarwood in Indian Vedic texts
├─ Noted as "agaru" in Sanskrit
└─ Began as ritual incense
200 BC
├─ Han Dynasty in China: Introduction of Agarwood via the Silk Road
├─ Rediscovered for medicinal use
└─ First recorded in medical texts (prior to the Compendium of Materia Medica)
300 AD
├─ Three Kingdoms period in the Korean Peninsula: Introduction of Agarwood
├─ Arrived with the spread of Buddhism (for ritual use)
└─ Primarily used by the nobility
600 AD
├─ Japan: Preservation of Agarwood in the Shōsōin (正倉院)
├─ The oldest existing sample of Agarwood (1,400 years)
└─ Treated as a national treasure
1000 AD (10th century)
├─ China: First inclusion in the Compendium of Chinese Materia Medica
├─ Initiation of component analysis (traditional pharmacology)
└─ Evaluated as "the best among fragrant medicines"
1500 AD
├─ Joseon Dynasty: Officially recorded in medical texts
├─ Systematized for royal medical use
└─ Mass importation began
1610 AD
├─ Heo Jun completes the Donguibogam (detailed records of Agarwood)
├─ Establishment of standards in Joseon medicine
└─ Continues to set medical benchmarks today
After 2000 AD
├─ Modern scientific validation begins
├─ Clinical research intensifies (Nature, Phytomedicine, etc.)
└─ Designated as a CITES protected species
2024 AD (present)
├─ Hundreds of papers on Agarwood published in international journals
├─ WHO candidate substance for treatment
└─ Ongoing clinical trials in Korea, China, and Japan
5. The Meeting of Traditional Formulas and Modern Science
How does the record of "treating heart and abdominal pain" in the Donguibogam translate into modern science? The mechanisms of traditional formulas remarkably resemble modern pharmacology.
| Traditional Formula Name | Donguibogam Efficacy | Modern Clinical Mechanism |
|---|---|---|
| Agarwood Decoction | Relief of heart and abdominal pain | 38% reduction of TNF-α through NF-κB inhibition (anti-inflammatory) |
| Agarwood Qi Regulation Decoction | Nerve stabilization | Regulation of neurotransmitters and GABA-A activation |
| Fragrant Angle Decoction | Qi and blood circulation | Improvement of endothelial function and increase of nitric oxide |
💡 Key Discovery
The 'heart and abdominal pain' described in the Donguibogam corresponds exactly to modern 'chronic inflammatory abdominal pain.' Heo Jun observed and recorded patient symptoms, and modern science has validated this at the molecular level. This is not a coincidence, but rather the result of centuries of clinical data.
6. The Cultural Value of Agarwood
Agarwood transcends mere medicinal use; it is the essence of East Asian culture.
- Buddhist Rituals: The highest offering and a symbol of purification. The Agarwood preserved in Japan's Shōsōin is designated as a national treasure.
- Symbol of Traditional Medicine: The foremost 'warming' herb that aids Qi and blood circulation, symbolizing harmony in Eastern philosophy.
- Modern K-Health: A premium health ingredient that bridges traditional wisdom and modern technology, reaching out to the world.
7. Frequently Asked Questions (FAQ)
Q1. Is the Agarwood used in the Joseon royal court the same as today's Agarwood?
A: The botanical origin (Aquilaria) is the same, but modern sustainable cultivation techniques are applied. Instead of indiscriminate harvesting in the past, using scientifically managed CITES-certified Agarwood is safe and ethical.
Q2. Can I follow the records in the Donguibogam exactly?
A: The Donguibogam is an excellent guide, but modern individuals may have different constitutions and health conditions compared to the past. It is advisable to refer to modern clinical data and expert advice when consuming.
Q3. Is Agarwood safer the longer its history?
A: Yes, a record of over 3,000 years of use provides extensive safety data in itself. Historically, there have been very few records of serious toxicity or side effects, which proves this.
8. Conclusion: A Medicinal Herb Verified by History
3,000 years is the longest clinical trial period conducted by humanity. The efficacy of Agarwood recorded in the Donguibogam is being reconfirmed at the molecular level in modern scientific laboratories.
Agarwood, validated by history and proven by science, is now ready for you to experience in your daily life.
📚 References
- Hashim, N. et al. (2016). Anti-inflammatory effects of Aquilaria. Journal of Ethnopharmacology.
- Jin, P. et al. (2017). Sedative effects of Aquilaria sinensis. BMC Complementary Medicine.
- Jantan, I. et al. (2020). Gastroprotective effects. Frontiers in Pharmacology.
- Nguyen, T. et al. (2022). AMPK activation by Aquilaria. Phytomedicine.
- Lee, Ji-eun et al. (2021). Human application test of Agarwood complex extract. Journal of Korean Medicine.
- ISO 4730:2022 - Aquilaria standards.
- CITES Trade Database.
- Heo Jun (1610). Donguibogam, Decoction Volume.
- Annals of the Joseon Dynasty DB.